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Unteers' lung found significant decreases in levels of SP-A [28]. Unfortunately, there was little overlap in the sets of identified proteins between our studies and therefore little basis for comparison. When the DEF and RED proteins are individually examined as subgroups of the identified proteins, the changes are similar to those noted for all proteins. In both of these groups of proteins, more
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Between 4 hours and 24 hours post infection (Continued)57 60 Serine (or cysteine) proteinase inhibitor, clade A, member 1e Tyrosine-3-monooxygenase/tryptophan 5-monooxynase activation protein, Epsilon polypeptide Q00898 Q8BPH1 -9.83 33.02 -3.86 4.Changes ( ) in BAL protein expression that were similar for wild-type (WT) and SP-A-/- mice between 4 and 24 hours post infection are shown. Gel numbers
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Han WT mice both at baseline (-23.3 ) and after 4 hr of infection (-89.53 ), but by the 24 hour time point its levels weremarkedly higher in the SP-A-/- mice (93.8 ), indicating a delayed response in the SP-A-/- mice. c) Potential pathways affected by changes We also used the Ingenuity Systems Pathways Analysis program to better understand the functional implications of the absence of SP-A, both u

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