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Creased expression of IL-33 in epithelial cells.216 Upon tissue damage induced by viral infection, this increased supply of IL-33 is released and exacerbates inflammation. Interestingly, the authors also demonstrated that cigarette smoke induced a shift in the type of immune response by controlling the expression of ST2 and IL-1R3. Indeed, cigarette smoke induced a dramatic decrease in ST2/IL-1R3

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