Ssion of the different S100 proteins is cell dependent and is regulated by specific growth factors, cytokines or activation of cell surface PRRs.225,227 Most S100 proteins are of rather small size (14 kDa) and are encoded by genes clustered on chromosome 1q21.228 One interesting exception to this rule is S100B, the coding gene of which is located on chromosome 21q22.3 and is found to be overexpres
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